Charming setter wearing women's pants (7)
I believe the answer is:
winsome
'charming' is the definition.
(thesaurus)
'setter wearing women's pants' is the wordplay.
'setter' becomes 'i' (the person that set the crossword).
'wearing' indicates putting letters inside.
'pants' indicates anagramming the letters (UK informal term for 'nonsense' or 'rubbish').
'womens' anagrammed gives 'wnsome'.
'i' put into 'wnsome' is 'WINSOME'.
(Other definitions for winsome that I've seen before include "Appealingy attractive" , "Fetching" , "Holding an appeal" , "Pleasant" , "Captivating" .)