Cheat misguided twits (5)
I believe the answer is:
twist
'cheat' is the definition.
(I've seen this before)
'misguided twits' is the wordplay.
'misguided' indicates anagramming the letters (letters guided into the wrong places).
'twits' with letters rearranged gives 'TWIST'.
(Other definitions for twist that I've seen before include "Cheat; unexpected plot development" , "Deal me another card! - distort" , "Writhe" , "quirk?" , "Boy wanting more" .)