Cheeky girls from north overcome by cocktails (6)
I believe the answer is:
minxes
'cheeky girls' is the definition.
'north overcome by cocktails' is the wordplay.
'north' becomes 'n' ('N' can be a synonym of 'north').
'overcome by' is an insertion indicator.
'cocktails' becomes 'mixes'.
'n' going within 'mixes' is 'MINXES'.
'from' is the link.
(Other definitions for minxes that I've seen before include "Cheeky or mischievous girls" , "Seductive women" .)