Cheers following pub departure (10)
I believe the answer is:
innovation
'departure' is the definition.
(an innovation is a departure from the norm)
'cheers following pub' is the wordplay.
'cheers' becomes 'ovation'.
'following' is a charade indicator (letters next to each other).
'pub' becomes 'inn' (I've seen this before).
'ovation' after 'inn' is 'INNOVATION'.
(Other definitions for innovation that I've seen before include "Something new" , "Something introduced as a novelty" , "What's new" , "New product" , "original" .)