Children of Susie? (5)
I believe the answer is:
issue
'children' is the definition.
(issue can mean someone's offspring)
'of susie?' is the wordplay.
'of' indicates an anagram (the answer comes from or 'of' the letters).
'susie' anagrammed gives 'ISSUE'.
(Other definitions for issue that I've seen before include "Point in dispute" , "Outcome - children" , "Question in dispute to be settled" , "Send out or distribute for use" , "Publish - put into circulation" .)