Chills and fever (4)
I believe the answer is:
ague
'chills and fever' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for ague that I've seen before include "Fever with shivers" , "Acute fever; shivering fit" , "Malarial fever or fit of shivering" , "met with cheek in Twelfth Night" , "Malaria, for example" .)