Choir resigns in distress (7)
I believe the answer is:
singers
'choir' is the definition.
(a choir is a group of singers)
'resigns in distress' is the wordplay.
'in distress' indicates an anagram.
'resigns' anagrammed gives 'SINGERS'.
(Other definitions for singers that I've seen before include "Eg, choir members" , "Chorus" , "Choristers" , "See 26" , "eg Tenors" .)