Choke with fourth of cream crackers (4)
I believe the answer is:
gaga
'crackers' is the definition.
(I've seen this before)
'choke with fourth of cream' is the wordplay.
'choke' becomes 'gag' (synonyms).
'with' is a charade indicator (letters next to each other).
'fourth of cream' becomes 'a' (4th letter of 'cream').
'gag'+'a'='GAGA'
(Other definitions for gaga that I've seen before include "crackers" , "fatuous?" , "Foolishly doting" , "bananas" , "Slang for crazy - apply a gag" .)