Chopin amused at heart by this work (4)
I believe the answer is:
opus
'chopin amused at heart by this work' is the definition.
'opus' can be an answer for 'work' (an opus is an artistic work). I'm not certain of the rest of the definition.
'amused at heart by this work' is the wordplay.
'at heart' says to take the centre.
'by' means one lot of letters go next to another.
'this work' becomes 'op' (short for opus).
The middle of 'amused' is 'us'.
'us' put after 'op' is 'OPUS'.
Can you help me to learn more?
(Other definitions for opus that I've seen before include "Work (of a composer?)" , "Composition - magnum __" , "Work or composition, usually musical" , "Composer's catalogue number" , "Composer's work" .)