CIA deny mixing poison (7)
I believe the answer is:
cyanide
'poison' is the definition.
(cyanide is poisonous)
'cia deny mixing' is the wordplay.
'mixing' is an anagram indicator.
'cia'+'deny'='ciadeny'
'ciadeny' anagrammed gives 'CYANIDE'.
(Other definitions for cyanide that I've seen before include "killer" , "Nice day (anag) - poison" , "Toxic salt" , "Highly toxic substance" , "Poisonous compound" .)