CIA men destroyed picture-house (6)
I believe the answer is:
cinema
'picture-house' is the definition.
(I've seen this before)
'cia men destroyed' is the wordplay.
'destroyed' is an anagram indicator.
'cia'+'men'='ciamen'
'ciamen' anagrammed gives 'CINEMA'.
(Other definitions for cinema that I've seen before include "Screening" , "Movie-house" , "Modern art" , "(Building for) film" , "Filmdom" .)