City in great trouble (7)
I believe the answer is:
tangier
'city' is the definition.
(city in Morocco)
'in great trouble' is the wordplay.
'trouble' indicates anagramming the letters.
'in'+'great'='ingreat'
'ingreat' anagrammed gives 'TANGIER'.
(Other definitions for tangier that I've seen before include "with more piquant flavour" , "North African port" , "Granite city just opposite Gibraltar" , "More piquant - Moroccan port" , "Rather spicy" .)