City is in Pennsylvania? Yes and no (4)
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I believe the answer is:
pisa
'city' is the definition.
(Pisa is an example)
I can't explain the rest of the clue.
(Other definitions for pisa that I've seen before include "Site of the famous leaning tower" , "City with listed building" , "There's a marked inclination here" , "Italian city with famous tower" , "City on the River Arno" .)