City left with nothing (5)
I believe the answer is:
porto
'city' is the definition.
(I have seen 'Portuguese city ' mean 'porto' so perhaps 'city' could also mean 'porto')
'left with nothing' is the wordplay.
'left' becomes 'port' (left side of a ship - opposite of starboard).
'with' says to put letters next to each other.
'nothing' becomes 'O' (O resembles 0).
'port'+'o'='PORTO'
(Other definitions for porto that I've seen before include "City on the Douro estuary" , "City in NW Portugal (Portuguese spelling)" , "Portuguese wine city on the Douro" , "City port of Portugal" , "champion of Europe" .)