City of changing moods (5)
I believe the answer is:
sodom
'city' is the definition.
(cities of the plain from Genesis)
'changing moods' is the wordplay.
'changing' indicates an anagram.
'moods' with letters rearranged gives 'SODOM'.
'of' acts as a link.
(Other definitions for sodom that I've seen before include "Corrupt biblical city" , "Place near Gomorrah" , "Vicious city" , "Wicked OT city" , "Twin town to Gomorrah" .)