City of strange moods (5)
I believe the answer is:
sodom
'city' is the definition.
(cities of the plain from Genesis)
'strange moods' is the wordplay.
'strange' indicates an anagram.
'moods' anagrammed gives 'SODOM'.
'of' acts as a link.
(Other definitions for sodom that I've seen before include "The piece of turf starts the wicked city" , "Vicious city" , "Wicked town of ancient Palestine, twinned with Gomorrah" , "Twin town to Gomorrah" , "den of vice" .)