City of tireless enterprise (5)
I believe the answer is:
essen
'city' is the definition.
(Essen is an example)
'of tireless enterprise' is the wordplay.
'of' says the answer is hidden in the clue.
'ESSEN' is hidden in the letters of 'tireless enterprise'.
(Other definitions for essen that I've seen before include "European city" , "Krupp HQ (Ger.)" , "German place name" , "Industrial centre of the Ruhr" , "city in the Ruhr valley" .)