City to remain in receipt of second great joy (7)
I believe the answer is:
ecstasy
'great joy' is the definition.
(I've seen this before)
'city to remain in receipt of second' is the wordplay.
'city' becomes 'ec' (the City of London postcode).
'to remain' becomes 'stay' ('stay' can be a synonym of 'remain').
'in receipt of' means one lot of letters goes inside another.
'second' becomes 's' (common abbreviation).
'stay' going around 's' is 'stasy'.
'ec'+'stasy'='ECSTASY'
(Other definitions for ecstasy that I've seen before include "Youth drug or unalloyed bliss" , "Rapture; drug" , "State of rapture" , "Delirium as from youth drug" , "Feeling of immense rapture" .)