City's ruler looked down on by senior woman (7)
I believe the answer is:
nanking
'city's' is the definition.
(Nanking is an example)
'ruler looked down on by senior woman' is the wordplay.
'ruler' becomes 'king' (king is a kind of ruler).
'looked down on by' means one lot of letters go next to another (some letters go above others).
'senior woman' becomes 'nan'.
'king' put after 'nan' is 'NANKING'.
(Other definitions for nanking that I've seen before include "Port" , "Oriental city" , "Chinese city" , "Eastern city" .)