Clear instruction from Pope on sleep (8)
I believe the answer is:
bulldoze
'clear' is the definition.
(to bulldoze something is to clear or remove it)
'instruction from pope on sleep' is the wordplay.
'instruction from pope' becomes 'bull' (as in a papal bull).
'on' says to put letters next to each other.
'sleep' becomes 'doze' (I've seen this before).
'bull'+'doze'='BULLDOZE'
(Other definitions for bulldoze that I've seen before include "get level" , "Completely flatten" , "Knock flat" , "Clear earth with powerful machine, or force through" , "Clear with powerful tractor, demolish" .)