Clue is roundly trashed in a cynical manner (13)
I believe the answer is:
incredulously
'in a cynical manner' is the definition.
(in a disbelieving manner)
'clue is roundly trashed' is the wordplay.
'trashed' is an anagram indicator.
'clue'+'is'+'roundly'='clueisroundly'
'clueisroundly' with letters rearranged gives 'INCREDULOUSLY'.
(Another definition for incredulously that I've seen is " viewed with scepticism".)
I've seen this clue in The Times.
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