Clue to new gains lost (6)
I believe the answer is:
signal
'clue' is the definition.
(thesaurus)
'new gains lost' is the wordplay.
'new' indicates anagramming the letters.
'lost' becomes 'l' (this could be a standard abbreviation I've not previously seen).
'gains' anagrammed gives 'signa'.
'signa'+'l'='SIGNAL'
'to' acts as a link.
Can you help me to learn more?
(Other definitions for signal that I've seen before include "(Traffic) light" , "Gesture or object giving information" , "Indication; a train control" , "Gesture encoding a message" , "See 7" .)