Co-star with Eric Sykes in the 1970s sitcom 'Sykes' (6,7)

I believe the answer is:

carbon dioxide

(Other definitions for carbon dioxide that I've seen before include "Gas breathed out" , "Gas formed by breathing out" , "This one might expire" , "Gas produced in breathing" , "Greenhouse gas" .)

I've seen this clue in The Telegraph.

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