Columbus's birthplace (5)
I believe the answer is:
genoa
'columbus's birthplace' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for genoa that I've seen before include "Italian city; sail" , "Italian city has no age, oddly" , "City of Italy" , "Type of rich fruit cake" , "Seaport in northwestern Italy" .)