Comedian suppressing nasty oath over female -- why should that be considered significant? (4,2,2)
I believe the answer is:
what of it
'why should that be considered significant?' is the definition.
('what of it?' means 'why does that matter?')
'comedian suppressing nasty oath over female' is the wordplay.
'comedian' becomes 'wit' (a witty person).
'suppressing' indicates putting letters inside.
'nasty' indicates anagramming the letters.
'over' means one lot of letters go next to another.
'female' becomes 'f' (abbreviation).
'oath'+'f'='oathf'
'oathf' with letters rearranged gives 'hatof'.
'wit' going around 'hatof' is 'WHAT OF IT?'.
(Another definition for what of it that I've seen is " does it matter?".)