Comedian’s cry of pain? (6)
I believe the answer is:
scream
This clue is a double definition.
'comedian's' is the first definition.
(I've seen this before)
'cry of pain?' is the second definition.
(a scream might indicate pain)
(Other definitions for scream that I've seen before include "A long piercing cry as of terror" , "Caution" , "funny man" , "Make a piercing sound" , "Extremely funny entertainer" .)