Comedy sketch about queen’s dress (5)
I believe the answer is:
skirt
'dress' is the definition.
(thesaurus)
'comedy sketch about queen's' is the wordplay.
'comedy sketch' becomes 'skit' (I've seen this before).
'about' indicates putting letters inside.
'queen' becomes 'r' (r is abbreviation regina. e.g. in ER ).
'skit' enclosing 'r' is 'SKIRT'.
(Other definitions for skirt that I've seen before include "Garment below the waist" , "Leave the pack" , "Feminine item of clothing" , "Go round the edges of" , "Go round edge" .)