Comfort about female swallowing deceit (6)
I believe the answer is:
relief
'comfort' is the definition.
(relief is a kind of comfort)
'about female swallowing deceit' is the wordplay.
'about' becomes 're' (regarding**).
'female' becomes 'f' (abbreviation).
'swallowing' means one lot of letters goes inside another.
'deceit' becomes 'lie' (I've seen this in other clues).
're'+'f'='ref'
'ref' placed around 'lie' is 'RELIEF'.
(Other definitions for relief that I've seen before include "Easement from pain or distress" , "That's a load off my mind" , "Freeing of besieged city" , "Relaxation following distress" , "Break" .)