Commercial centre with mail shot (10)
I believe the answer is:
mercantile
'commercial' is the definition.
('mercantile' can be similar in meaning to 'commercial')
'centre with mail shot' is the wordplay.
'with' is a charade indicator (letters next to each other).
'shot' indicates an anagram.
'centre' after 'mail' is 'mailcentre'.
'mailcentre' anagrammed gives 'MERCANTILE'.
(Other definitions for mercantile that I've seen before include "related to business" , "Commercial" , "concerning trade" , "Dealing with trade" , "Relating to trade or commerce" .)