Commercial holding in Fox News's ending in dispute (2,4)
I believe the answer is:
at odds
'in dispute' is the definition.
'commercial holding in fox news's ending' is the wordplay.
'commercial' becomes 'ad'.
'holding in' means one lot of letters goes inside another.
'fox' becomes 'tod' (historic term).
'ending' indicates one should take the final letters.
The final letter of 'newss' is 's'.
'ad' going around 'tod' is 'atodd'.
'atodd'+'s'='AT ODDS'
(Other definitions for at odds that I've seen before include "Quarrelling" , "Opposed, in conflict with" , "In disagreement or conflict - like bookies?" , "Conflicting (with)" , "At variance (with)" .)