Complaint from male to a female (6)
I believe the answer is:
malady
'complaint' is the definition.
(thesaurus)
'from male to a female' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'male' becomes 'm' (common abbreviation).
'to' says to put letters next to each other (I've seen this in other clues).
'female' becomes 'lady' (lady is a kind of female**).
'm' put after 'a' is 'am'.
'am' anagrammed gives 'ma'.
'ma'+'lady'='MALADY'
(Other definitions for malady that I've seen before include "Disease, ailment" , "hay fever, perhaps" , "Disease or disorder" , "Illness or disease" , "Complaint" .)