Completely tough Roth novel about university (10)
I believe the answer is:
throughout
'completely' is the definition.
(thesaurus)
'tough roth novel about university' is the wordplay.
'novel' indicates anagramming the letters.
'about' is an insertion indicator.
'university' becomes 'u'.
'tough'+'roth'='toughroth'
'toughroth' is an anagram of 'throughot'.
'throughot' going around 'u' is 'THROUGHOUT'.
(Other definitions for throughout that I've seen before include "Completely" , "from start to finish" , "Everywhere" , "during the entire proceedings" , "all the time" .)