Compound starts to affect me, infecting nerve endings (5)
I believe the answer is:
amine
'compound' is the definition.
(amine is a kind of compound)
'starts to affect me infecting nerve endings' is the wordplay.
'starts to' suggests taking the first letters.
The first letters of 'affect me infecting nerve endings' is 'AMINE'.
(Another definition for amine that I've seen is " basic compound".)
I've seen this clue in The Telegraph.
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