Compulsive desire (4)
I believe the answer is:
itch
'compulsive desire' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for itch that I've seen before include "Strong desire to do something" , "great desire" , "Impatient desire (colloq.)" , "Niggling skin sensation" , "Long" .)