Computer system news chief’s given a shot (5)
I believe the answer is:
dosed
'given a shot' is the definition.
The answer and definition can be both related to change as well as being past participle verbs.
Perhaps they are linked in a way I don't understand?
'computer system news chief's' is the wordplay.
'computer system' becomes 'dos' (I am not sure about this - if you are sure you should believe this answer much more).
'news chief' becomes 'ed' (I've seen this in other clues).
'dos'+'ed'='DOSED'
Can you help me to learn more?
(Other definitions for dosed that I've seen before include "Given shot" , "Administered a portion of medicine to" , "Given medicine" , "Given a drug" , "Gave medicine to" .)