Concern about being in charge in isolation (10)
I believe the answer is:
solicitude
'concern' is the definition.
(I know that solicitude is a type of concern)
'about being in charge in isolation' is the wordplay.
'about' shows that the letters should be reversed in order.
'being in charge' becomes 'ic' (abbreviation for 'in charge').
'in' means one lot of letters goes inside another.
'isolation' becomes 'solitude' (solitude is a kind of isolation).
'ic' backwards is 'ci'.
'ci' going into 'solitude' is 'SOLICITUDE'.
(Other definitions for solicitude that I've seen before include "Feeling of excessive concern" , "Care, concern" .)