Concocted by a don, it fights harmful substances (8)
I believe the answer is:
antibody
'concocted by a don it fights harmful substances' is the definition.
I can't tell whether this defines the answer.
'concocted by a don it' is the wordplay.
'concocted' indicates an anagram.
'by'+'a'+'don'+'it'='byadonit'
'byadonit' is an anagram of 'ANTIBODY'.
Can you help me to learn more?
(Other definitions for antibody that I've seen before include "Antigen attacker" , "Fighter in blood" , "protection against disease" , "Pathogen fighter" , "Immune system protein" .)