Conduct dire matins when drunk (10)
I believe the answer is:
administer
'conduct' is the definition.
(thesaurus)
'dire matins when drunk' is the wordplay.
'when drunk' indicates an anagram (I've seen this in other clues).
'dire'+'matins'='dirematins'
'dirematins' anagrammed gives 'ADMINISTER'.
(Other definitions for administer that I've seen before include "Organise" , "man?" , "conduct" , "Deal out (punishment)" , "Run" .)