Confirmation neglected woman struggles to save a thousand (15)
I believe the answer is:
acknowledgement
'confirmation' is the definition.
(to confirm is to acknowledge as legitimate)
'neglected woman struggles to save a thousand' is the wordplay.
'struggles' indicates an anagram.
'to save' means one lot of letters goes inside another.
'a thousand' becomes 'K' (synonyms).
'neglected'+'woman'='neglectedwoman'
'neglectedwoman' anagrammed gives 'acnowledgement'.
'acnowledgement' enclosing 'k' is 'ACKNOWLEDGEMENT'.
(Other definitions for acknowledgement that I've seen before include "profession" , "Confession; thanks" , "admission" .)