Conflict? Wife has trouble with it (6)
I believe the answer is:
strife
This clue is a double definition.
'conflict?' is the first definition.
(strife is a kind of conflict)
'wife has trouble with it' is the second definition.
('trouble and strife' is rhyming slang for 'wife')
(Other definitions for strife that I've seen before include "Heated discord" , "Bitter conflict" , "Struggle" , "Warfare" , "Conflict, dispute" .)