Confuse extremists in Delaware (4)
I believe the answer is:
daze
'confuse' is the definition.
(thesaurus)
'extremists in delaware' is the wordplay.
'extremists' becomes 'az' (I've seen this in other clues).
'in' means one lot of letters goes inside another.
'delaware' becomes 'de' (standard two letter abbrev).
'az' put into 'de' is 'DAZE'.
(Other definitions for daze that I've seen before include "Benumb" , "Haze, befuddlement" , "Bewilder" , "State of stupor" , "Make to feel stunned or bewildered" .)