Confusion as fraternity takes over large university (9)
I believe the answer is:
ambiguity
'confusion' is the definition.
(thesaurus)
'fraternity takes over large university' is the wordplay.
'fraternity takes' becomes 'amity' (I can't justify this - if you can you should believe this answer much more).
'over' is an insertion indicator.
'large' becomes 'big' (synonyms).
'university' becomes 'U' (abbreviation for university).
'big'+'u'='bigu'
'amity' going around 'bigu' is 'AMBIGUITY'.
'as' acts as a link.
Can you help me to learn more?
(Other definitions for ambiguity that I've seen before include "Uncertainty of meaning" , "Double meaning" , "Equivocal expression" , "Something open to differing interpretations" , "Lack of a single meaning" .)