Consider ways to be prolific (6)
I believe the answer is:
esteem
'consider' is the definition.
(I know that esteem is a type of consider)
'ways to be prolific' is the wordplay.
'ways' becomes 'es' (east and south - two directions).
'to be prolific' becomes 'teem' (I've seen this before).
'es'+'teem'='ESTEEM'
(Other definitions for esteem that I've seen before include "Respect, admire" , "Revere(nce)" , "Floor covering" , "Admiration, regard" , "Honour - regard" .)