Contact America? You'll want thick skin! (6)
I believe the answer is:
callus
'thick skin' is the definition.
(thesaurus)
'contact america?' is the wordplay.
'contact' becomes 'call'.
'america?' becomes 'U.S.' (United States).
'call'+'us'='CALLUS'
'you'll want' is the link.
This may not be right. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for callus that I've seen before include "Area of hard skin" , "This thick-skinned" , "Skin problem" , "Thickened skin patch" , "A sore point" .)