Contradicts remark in profits (8)
I believe the answer is:
gainsays
'contradicts' is the definition.
(I've seen this before)
'remark in profits' is the wordplay.
'remark' becomes 'say'' (to remark something is to say it).
'in' indicates putting letters inside.
'profits' becomes 'gains' ('gain' can be a synonym of 'profit').
'say' going within 'gains' is 'GAINSAYS'.
(Other definitions for gainsays that I've seen before include "What a 10 [CONRARIAN] does" , "Denies, contradicts" .)