Contrary, harmful (7)
I believe the answer is:
adverse
This clue is a double definition.
'contrary' is the first definition.
(synonyms)
'harmful' is the second definition.
(synonyms)
(Other definitions for adverse that I've seen before include "Hostile" , "Contrary -- inauspicious" , "Inimical" , "Detrimental" , "Unfavourable or harmful, perhaps criticism" .)