Cope with it being muddled, like much of Shakespeare! (6)
I believe the answer is:
poetic
'like much of shakespeare' is the definition.
(Shakespeare's writing is often poetic)
'cope with it being muddled' is the wordplay.
'with' means one lot of letters go next to another.
'being muddled' indicates anagramming the letters.
'cope' put after 'it' is 'itcope'.
'itcope' is an anagram of 'POETIC'.
(Other definitions for poetic that I've seen before include "Clearly expressed in speech/writing" , "Written in verse" , "rhythmical" , "Flowery" , "Concerning metrical writing" .)