Cordial about head of human skeleton (7)
I believe the answer is:
chassis
'skeleton' is the definition.
(I know that chassis is a type of skeleton)
'cordial about head of human' is the wordplay.
'cordial' becomes 'cassis' (type of cordial drink).
'about' means one lot of letters goes inside another.
'head of' suggests taking the first letters.
The initial letter of 'human' is 'h'.
'cassis' enclosing 'h' is 'CHASSIS'.
(Other definitions for chassis that I've seen before include "Car framework" , "Undercarriage" , "sash" , "it strengthens the body" , "Vehicle base frame" .)