Corrupt leaders in thrash arranged inside Number Ten (5)
I believe the answer is:
taint
'corrupt' is the definition.
(I know that corrupt can be written as taint)
'leaders in thrash arranged inside number ten' is the wordplay.
'leaders in' suggests taking the first letters.
The initial letters of 'thrash arranged inside number ten' is 'TAINT'.
(Other definitions for taint that I've seen before include "soil" , "Flaw in Titan" , "Adulterate" , "Evidence of pollution" , "Blemish" .)