Corrupt, sleeping over, Salome drained (6)
I believe the answer is:
debase
'corrupt' is the definition.
(synonyms)
'sleeping over salome drained' is the wordplay.
'sleeping' becomes 'abed' (I've seen this before).
'over' says the letters should be written backwards.
'drained' means to remove the middle letters.
'salome' with its centre taken out is 'se'.
'abed' reversed gives 'deba'.
'deba'+'se'='DEBASE'
(Other definitions for debase that I've seen before include "Degrade or devalue" , "Lower in quality, reduce the value of" , "Degrade or demean" , "Make lower in prestige or esteem" , "Lower in quality or value, corrupt" .)